Scale-up and Optimization in Preparative Chromatography: Principles and Biopharmaceutical Applications
edited by Anurag S. Rathore, Ajoy Velayudhan
Publisher: Hoboken : Marcel Dekker Inc, 2002.
ISBN: 0824708261
DDC: 543.089
Summary:
This text offers fundamental analysis of the underlying
physicochemical principles to select optimal modes of interaction,
design efficient separations, and increase productivity in the
manufacture of novel therapeutics and pharmaceuticals.
Notes:
Preface; Contents; Contributors; An Overview of Scale-Up in
Preparative Chromatography; Interaction of Mass Transfer and Fluid
Mechanics; Optimization of Preparative Separations; Engineering
Aspects of Ion-Exchange Chromatography; A Simple Approach to Design
and Control of Simulated Moving Bed Chromatographs; Large-Scale
Ion-Exchange Chromatography: A Comparison of Different Column
Formats; Development and Operation of a Cation-Exchange
Chromatography Process for Large-Scale Purification of a Recombinant
Antibody Fragment.
Case Study: Capacity Challenges in Chromatography-Based Purification
of Plasmid DNACase Study: Purification of an IgG1 Monoclonal
Antibody; Case Study: Normal Phase Purification of Kilogram
Quantities of a Synthetic Pharmaceutical Intermediate; Case Study:
Development of Chromatographic Separation to Remove Hydrophobic
Impurities in Alatrofloxacin; Case Study: Process Development of
Chromatography Steps for Purification of a Recombinant E. coli
Expressed Protein; Index.
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