Neurochemical Aspects of Excitotoxicity
Akhlaq A. Farooqui, Wei-Yi Ong, Lloyd Horrocks,Publisher: Springer
ISBN: 0387730222 ISBN13: 9780387730226 DDC: 573 Edition: Hardcover; 2007-10-17
Summary:
About 40% of central nervous system synapses use glutamate as theneurotransmitter. Over-stimulation of glutamate receptors produces
neuronal injury or death by excitotoxicity, which is closely
associated with neurochemical and neuropathological changes involved
in acute neural trauma (stroke, spinal cord trauma, and head injury)
and neurodegenerative diseases such as Alzheimer disease, Parkinson
disease, Huntington disease, amyotrophic lateral sclerosis (ALS),
Creutzfeldt-Jakob disease, Guam-type amyotrophic lateral
sclerosis/Parkinson dementia (ALS/PDC), and multiple sclerosis. In
the past decade, our understanding of the biochemistry, molecular
biology, and neuropathology of the glutamate transporters and
receptors has exploded. It is becoming increasingly evident that
molecular mechanisms, which govern the transfer of the death signal
from the neural cell surface to the nucleus, depend on lipid
mediators and on cross talk among excitotoxicity, oxidative stress,
and neuroinflammation, and that interactions among these three
processes play a major role in neuronal cell death during acute
neural trauma and neurodegenerative disease. These processes may be
primary initiating points in neurodegeneration or they may be the end
result of the neurodegenerative process itself. Neurochemical Aspects
of Excitotoxicity provides extensive insight into glutamate
transporters and receptors, including their role in the brain with
other neurochemical parameters in excitotoxicity, and possible
treatments. This book will be of interest scientists already working
in the field of excitotoxicity who are interested in gaining a
broader understanding of this complicated subject area, as well as
graduate students and neurologists who are curious about a common
cause of neuronal injury and neurological disorders.
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Book Details:
Physical Description: 6.4"x9.3"x1.1"; 1.1 lb; 290 pagesEdition Info: Hardcover; 2007-10-17
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Libraries this book has an entry in:
| • | Colorado State University (Fort Collins, CO) (last modified on 07/25/2012) |
| • | Ohio State University (last modified on 05/06/2011) |
| • | Colorado Unified Catalog (Prospector) (last modified on 01/28/2009) |