Metabolomics: A Powerful Tool in Systems Biology
Metabolomics: A Powerful Tool in Systems Biology (Topics in Current Genetics) Jens Nielsen (Editor), Michael C. Jewett (Editor)
Publisher: Springer
ISBN: 3540747184
DDC: 612.39
Edition: Hardcover; 2007-11-20
Summary:
The metabolome comprises the complete set of metabolites, the
non-genetically encoded substrates, intermediates, and products of
metabolic pathways, associated with a cell. Given the increasing
demand to quantitatively identify the metabolome and understand how
trafficking of metabolites through the metabolic network impact
cellular behavior, metabolomics has emerged as an important
complementary technology to the cell-wide measurements of mRNA,
proteins, fluxes, and interactions (e.g., protein-DNA). Metabolomics
is already a powerful tool in drug discovery and development and in
metabolic engineering. While maintaining these strengths, the field
promises to play a heightened role in systems biology research, which
is transforming the practice of medicine and our ability to engineer
living organisms. This book brings together the latest results in the
field of metabolomics. It comprehensively presents the current state
of the metabolomics field by underscoring experimental methods,
analysis techniques, standardization practices, and advances in
specific model systems. As a result, it significantly broadens our
perspective on the principles and strategies underpinning this
emerging field.
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