Índice: 1. Osteoclast: origin and differentiation. 2. Osteolytic
enzymes of osteoclasts. 3. Regulation of osteoclast activity. 4.
Structural aspects of bone resorption. 5. Inflammatory Cytokines. 6.
Genetics and mutations affecting osteoclast development and function.
7. Clinical disorders associated with alterations in bone resorption.
8. Pharmaceuticals for bone disease targeting the osteoclast. 9.
Skeletal complications of malignancy: central role for the
osteoclast.
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