Apoptosis And Its Relevance to Autoimmunity
Apoptosis And Its Relevance to Autoimmunity (Current Directions in Autoimmunity) Keith B. Elkon (Editor)
Publisher: S. Karger AG (Switzerland)
ISBN: 3805580363
DDC: 616.978
Edition: Hardcover; 2005-12-31
Summary:
Over the last 15 years, apoptosis has become a dominant focus of
medical research in the field of immunology. This publication
discusses the three major areas of apoptosis research: extrinsic
death receptor pathways, intrinsic cell death pathways and the
mechanisms responsible for apoptotic cell clearance. Each section
delineates the proteins and signal transduction pathways and
describes genetic alterations that lead to autoimmune diseases.
Although most cell death abnormalities have been associated with
systemic autoimmune disorders such as lupus erythematosus and
lymphoproliferative syndromes, it is evident that regulation of cell
death is also pertinent to disease expression in many organ-specific
diseases such as rheumatoid arthritis and glomerulonephritis.This
volume highlights the recent advances in the basic mechanisms of
apoptosis and the application of that knowledge to understanding the
impact of defective apoptosis or defective clearance of apoptotic
cells on the immune function and the expression of disease. It is of
special interest to cell biologists, immunologists and clinicians.
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