Volume 71 of Advances in Cancer Research begins with Morgan and
Kastan presenting data on the roles of p53 and ATM in cell cycle
progression and cell death in response to DNA damage and how this
information may lead to targets for improved cancer therapies. Kok et
all. Review the methodological advantages and limitations to
localizing tumor suppressor genes, especially those on the short arm
of chromosome 3. Peltomaki and de la Chapelle describe research on
mismatch repair genes and their effects on colorectal cancer. McKenna
and Cotter present findings on the functions and failures of
apoptosis in the hematopoietic system. Ravitz and Wenner review TGF-B
and how it controls and affects cell cycle progression in a variety
of cell types. Andrew Simpson presents data on the mutation
frequencies of microsatellites in human carcinogenesis. Naor and
colleagues present research on a multitude of tumors expressing
levels of CD44 and discuss how CD44 may be used as a target for
cancer therapy. Luisa Villa discusses various aspects of HPV and the
potential clinical use of HPV testing in cervical cancer prevention
programs. Last, Disis and Cheever review the studies that define
HER-2/neu specific immunity in patients with cancer and the current
vaccine strategies for generating specific immunity.
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