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Advances in Pharmacology, 27: Conjugation-dependent Carcinogenicity and Toxicity of Foreign Compounds
Murad, Ferid 
Publisher: Elsevier
ISBN10: 0080581188 ISBN13: 9780080581187 DDC: 615.1 Edition: (electronic bk.)337.5 (UA)

Summary

Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental. Conjugation reactions have long been associated with the detoxification of xenobiotics. Recent studies suggest that Phase II reactions are an important mechanism for the bioactivation of xenobiotics. This special volume of Advances in Pharmacology features a two-color dust jacket.

Notes

Front Cover; Conjugation-Dependent Carcinogenicity and Toxicity of Foreign Compounds; Copyright Page; Contents; Contributors; Chapter 1. Historical Perspectives on Conjugation-Dependent Bioactivation of Foreign Compounds; Part I: Glutathione-Dependent Toxicity; Chapter 3. Enzymology of Cysteine S-Conjugate ?-Lyases; Chapter 4. Formation and Fate of Nephrotoxic and Cytotoxic Glutathione S-Conjugates: Cysteine Conjugate ?-Lyase Pathway; Chapter 5. Reversibility in Glutathione-Conjugate Formation; Chapter 6. Glutathione Conjugation as a Mechanism for the Transport of Reactive Metabolites. Chapter 7. Metabolism and Genotoxicity of DihaloalkanesChapter 8. Bioactivation of Thiols by One-Electron Oxidation; Chapter 9. Glutathione Mercaptides as Transport Forms of Metals; Part II: Sulfate Conjugate-Dependent Toxicity; Chapter 2. Carcinogen Activation by Sulfate Conjugate Formation; Part III: Glucuronide Conjugate-Dependent Toxicity; Part IV: Bioactivation and Bioconversion. Electronic reproduction.Available via World Wide Web.

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