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3-D Cell-Based Biosensors in Drug Discovery Programs
Kisaalita, William Ssempa 
Publisher: CRC
ISBN10: 1420073494 ISBN13: 9781420073492 DDC: 660 Edition: Hardcover; 2009-10-15

Summary

This book is based upon cutting-edge research conducted in the author's lab (Cellular Bioengineering), which over the past decade has developed a number of sophisticated techniques to facilitate use of 3D cell based assays or biosensors. This book uses data from peer-reviewed publications to conclusively justify use of 3D cell cultures in cell-based biosensors (assays) for (HTS). The majority of assays performed in accelerated drug discovery processes are biochemical in nature, but there is a growing demand for live cell-based assays. Unlike biochemical ones, cellular assays are functional approximations of in vivo biological conditions and can provide more biologically relevant information.

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